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關於 t-cell lymphoma ，我們在網路上蒐集到這些相關的討論、資訊與評價

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在t-cell lymphoma這個產品中，有6篇Facebook貼文，粉絲數超過5,816的網紅史丹福狂想曲，也在其Facebook貼文中提到， 一位50歲，有吸煙及飲酒習慣的男士因發燒、鼻塞及口腔潰瘍而求醫。口腔檢查顯示病人近門牙的地方出現牙肉及硬顎（hard palate）潰瘍，潰瘍有不規則的邊界。活組織檢查顯示病人患上結外鼻腔型NK/T細胞淋巴瘤（Extranodal NK/T-cell lymphoma, nasal type）。 ...

t-cell lymphoma 在 史丹福狂想曲 Facebook 的最讚貼文

史丹福狂想曲 By 史丹福狂想曲

2021-09-14 20:40:37 有 34 人按讚
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一位50歲，有吸煙及飲酒習慣的男士因發燒、鼻塞及口腔潰瘍而求醫。口腔檢查顯示病人近門牙的地方出現牙肉及硬顎（hard palate）潰瘍，潰瘍有不規則的邊界。活組織檢查顯示病人患上結外鼻腔型NK/T細胞淋巴瘤（Extranodal NK/T-cell lymphoma, nasal type）。

結外鼻腔型NK/T細胞淋巴瘤是一種惡名昭彰的淋巴癌，在亞洲地區特別常見。它由愛潑斯坦-巴爾病毒（Epstein-Barr virus）令到NK/T細胞異常地增生引起。顧名思義，這種淋巴癌大多影響鼻腔部分，可引起鼻中隔穿孔、硬齶穿孔、鼻樑洞穿性損傷等病徵。其他病徵包括發燒、肝脾腫大、血細胞減少等。治療的方案包括放射治療及化療（大多使用包含asparaginase的化療組合 ）。

圖片及個未取自以下刊登在《新英格蘭醫學期刊》（New England Journal of Medicine）的案例報告：

https://www.nejm.org/doi/full/10.1056/NEJMicm2100505?fbclid=IwAR280IBfKeRlOO20CGI75meAxatSJs20u0wevFBQjx

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t-cell lymphoma 在 Facebook 的最佳解答

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2021-08-25 09:44:55 有 59 人按讚
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【藥事知多D】一物兩用：維生素A酸

說到維生素A酸(Retinoic Acid)（俗稱「A酸」），很多人便會聯想到暗瘡藥，例如維A酸(Tretinoin)、異維A酸(Isotretinoin)。

對，A酸這類藥的其中一個用途，便是暗瘡。

不說不知道，A酸這類藥原來還有一種鮮為人知的用途……

這便是……

停！在揭曉答案前，藥罐子首先不妨在這裡簡單分享一下A酸的作用原理吧！

A酸這門派主要在跟維生素A酸受體(Retinoic Acid Receptors, RARs)、維生素A酸X受體(Retinoid X Receptors, RXRs)這兩類受體結合，然後這些受體便會充當轉錄因子(Transcription Factor)，調控基因的轉錄(Transcription)，從而控制細胞凋亡(Apoptosis)、細胞分化(Cell Differentiation)。[1]

其實這個作用原理便是一個提示了。

這話怎麼解？

因為這門派能夠影響細胞分化、細胞凋亡這兩個過程，所以有時候還可以用來治療癌症。

對，其中一些A酸還可以是一種化療藥，透過抑制細胞分化，干擾細胞周期，抑制癌細胞增殖或者誘發細胞凋亡，誘發體內癌細胞啟動細胞凋亡，導致癌細胞自動消失，達到殺滅癌細胞的效果。

這方面，常見的例子分別是Alitretinoin、Bexarotene。

一、Alitretinoin
　　
在藥理上，Alitretinoin是一種「百搭」致效劑，簡單說，便是一條百合匙，同時能夠跟各種不同的維生素A酸受體、維生素A酸X受體結合，治療癌症。
　　
暫時還是不太清楚具體的作用原理，只是知道Alitretinoin能夠治療卡波西氏肉瘤(Kaposi's Sarcoma)這種癌症。[1]

二、Bexarotene
　　
在藥理上，Bexarotene是一種選擇性維生素A酸X受體致效劑，顧名思義，主要跟維生素A酸X受體結合，治療癌症。
　　
暫時還是不太清楚具體的作用原理，只是知道Bexarotene能夠治療皮膚T細胞淋巴瘤(Cutaneous T-cell Lymphoma)這種癌症。[2]

最後因為A酸這門派能夠控制細胞分化、細胞凋亡，所以還可能會影響體內其他細胞分裂速度較快的正常細胞，例如胚胎(Embryo)，從而能夠干預胚胎進行正常的細胞分裂，干擾胎兒的正常發展。

這就是說，A酸大多擁有致畸性(Teratogenicity)，從而可能會增加孕婦誕下畸胎的風險。

（如欲了解更多用藥資訊，歡迎看看「小小藥罐子」網誌。）

💊💊💊💊💊💊💊
BLOG➡️http://pegashadraymak.blogspot.com/
IG➡️https://www.instagram.com/pegashadraymak/
YT➡️https://www.youtube.com/channel/UCQOMojMd6q7XnESMWwldPhQ

📕📕📕📕📕📕📕
著作➡️藥事知多D、用藥知多D、藥房事件簿、家居用藥攻略（各大書店有售）

Reference:
1. Sporn MB, Lippman SM. Chemoprevention of cancer. In: Kufe DW, Pollock PE, Weichselbaum RR, et al, eds. Cancer Medicine, 6th ed. Hamilton, Ontario, BC Decker, 2003:414-422.
2. Duvic M, Hymes K, Heald P, et al. Bexarotene is effective and safe for treatment of refractory advanced-state cutaneous T-cell lymphoma: multinational phase II-III trial results. J Clin Oncol. 2001;19:2456-2471.

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t-cell lymphoma 在 吳鈞鴻-犬貓腫瘤科醫師-豆漿醬油小馬爸 Facebook 的最佳解答

吳鈞鴻-犬貓腫瘤科醫師-豆漿醬油小馬爸 By 吳鈞鴻-犬貓腫瘤科醫師-豆漿醬油小馬爸

2019-06-25 23:47:38 有 64 人按讚
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【淋巴相關的腫瘤（主要是淋巴瘤）不同次分型，存活時間中位數】
（預估可以活多久？）

這也是昨天在廣播的時候，
楊醫師要求要加碼的部分(淋巴瘤)XD
其中我提到診斷淋巴瘤，
還是希望可以有採樣做病理！

很重要的原因就是不同的次分型(subtype)，
可能有截然不同的存活時間！
這張圖可以很清楚的看到這件事情
（不是B細胞就一定好，T細胞就絕對差）

#採樣還是很重要
#狗/ #淋巴瘤/ #淋巴癌/ #化療/ #存活時間

-
來源：Fourth Meeting of the European Canine Lymphoma Group
https://www.facebook.com/348359251917466/posts/2309202892499749?s=741488888&sfns=mo

-
備註
BL – Burkitt’s
（勃氏淋巴瘤，通常是很惡性的B細胞型）
AL – acute leukemia
（急性白血病）
TCLEB – T cell leukemia of English bulldogs (provisional diagnosis)
（英鬥T細胞型白血病，暫時的名稱）
HS – hepatosplenic lymphoma
（肝臟脾臟型）
CEL – cutaneous epitheliotrophic lymphoma
（皮膚親上皮型）
DSBCL – diffuse small B cell lymphoma (provisional diagnosis)
（瀰漫性小型B 細胞，暫時的名稱）
PTCL – peripheral T cell lymphoma
（周邊T細胞型）
nMZL – nodal marginal zone lymphoma
（結節邊緣區型）
DLBCL – diffuse large B cell lymphoma
（瀰漫性大型B 細胞）
LGL – large granular lymphocytic leukemia
（大顆粒性淋巴球性白血病）
B-CLL – B cell chronic lymphocytic leukemia
（慢性淋巴B細胞型白血病）
MCL – mantle cell lymphoma
（被套細胞型，B細胞）
TZL – T zone lymphoma
（T區型）
sMZL – splenic marginal zone lymphoma
（脾臟邊緣區型）
FL – follicular lymphoma
（濾泡型）

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社群媒體上有些相關的討論：
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There are many types of T-cell lymphoma, and each one has varying outcomes and survival rates. T-cell lymphomas are non-Hodgkin lymphomas ...

#73. Hepatosplenic T-Cell Lymphoma: Is A Cure Possible?

Hepatosplenic T-cell lymphoma (HSTCL) was first described as a distinct clinicopathologic entity in 1990. 1 HSTCL is a rare type of non-Hodgkin lymphoma that ...

#74. Biology and Molecular Pathogenesis of Mature T-Cell ...

Abstract. Peripheral T-cell lymphomas (PTCLs) constitute a highly heterogeneous group of hematological diseases with complex clinical and ...

#75. Peripheral T-Cell Lymphoma in the Neck: CT Findings of ...

OBJECTIVE: To describe the CT findings of lymph nodes of the neck involved in peripheral T-cell lymphomas (PTCL). MATERIALS AND METHODS: Twenty-seven ...

#76. What is Cutaneous T-Cell Lymphoma? - News Medical

Cutaneous T-cell lymphomas are a group of T-cell related cancers that mainly affect the skin. There are many different treatment options ...

#77. Peripheral T-Cell Lymphoma With a “Follicular” Pattern and ...

We suggest that the follicular growth pattern in this case of PTCL arose secondarily to tumor spread via the perifollicular sinus. Peripheral T-cell lymphomas ( ...

#78. Angioimmunoblastic - Pathology Outlines

A. Follicular dendritic cell proliferation and prominent high endothelial venules are classic features of angioimmunoblastic T cell lymphoma.

#79. Brasil - A difficult case of angioimmunoblastic T-cell lymphoma ...

Angioimmunoblastic T-cell lymphoma (AITL) is a malignancy of mature T-cells. It is characterized as a polymorphic lymphonodal lymphoid infiltrate ...

#80. Monitoring MRD Can Help Diagnose Cutaneous T-Cell ...

Monitoring MRD Can Help Diagnose Cutaneous T-Cell Lymphoma ... Researchers were able to use a next-generation sequencing assay to not only monitor ...

#81. Adult T-Cell Leukemia/Lymphoma - Allen Press

Adult T-cell leukemia/lymphoma is a malignant lymphoproliferative neoplasm of mature T cells caused by HTLV-1, with characteristic ...

#82. Dupilumab and cutaneous T-cell lymphoma - Journal of the ...

The 4 patients initially presumed to have atopic dermatitis subsequently received a diagnosis of cutaneous T-cell lymphoma.

#83. Future of T-Cell Lymphoma Treatment | MedPage Today

Peripheral T-cell lymphoma accounts for about 7% of all non-Hodgkin lymphoma cases. Over the last decade, new drugs have emerged for this ...

#84. Cutaneous T-cell Lymphoma (CTCL) Diagnostic Test - The ...

Unmet Need Cutaneous T-cell lymphoma (CTCL) is a form of non-Hodgkin's lymphoma of the skin.

#85. CAR T Cell Therapy for Lymphoma and Leukemia - University ...

... Cancer Center is proud to offer a highly specialized and highly personalized form of immunotherapy - CAR T-Cells - to treat non-Hodgkin lymphoma.

#86. T-cell Lymphoma - Medscape Education

Dr. Steve Rosen discusses the exciting new agents in development and the registries that are being compiled for T-cell lymphoma.

#87. Pathogenesis of Peripheral T Cell Lymphoma - Annual Reviews

Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of tumors derived from the neoplastic transformation of mature (i.e., post-thymic) T lymphocytes.

#88. Mantle Cell Lymphoma (MCL) - WebMD

Doctors aren't sure why people get mantle cell lymphoma. You can't "catch" it the way you do a cold. But scientists believe that most people ...

#89. Enteropathy-Type T Cell Lymphoma - Surgical Pathology ...

T cell lymphoma involving the gastrointestinal tract, expressing cytotoxic granule associated proteins, frequently associated with enteropathic changes ...

#90. Rare Lymphoma: More Than Just an Internal Attack

Cutaneous T-cell lymphoma (CTCL) is one of the most common forms of T-cell lymphoma. Unlike most lymphomas, which come with distinct ...

#91. FOR T-CELL LYMPHOMA - Yale Cancer Center

Angioimmunoblastic T-cell lymphoma (AITL) is a rare, fast- growing cancer typically diagnosed at an advanced stage. Treatment options have not improved for ...

#92. Ruxolitinib Appears Effective Across Peripheral T-Cell ...

Researchers determined ruxolitinib appears clinically effective across a variety of peripheral T-cell lymphoma subtypes.

#93. Understanding Cell Lines, Patient-Derived Xenograft and ...

Cutaneous T cell lymphoma (CTCL) is a spectrum of lymphoproliferative disorders caused by the infiltration of malignant T cells into the skin.

#94. For one early adopter, CAR T therapy means 18 months ...

For now, UCLA Health is offering one of the two treatments, for certain types of lymphoma — including diffuse large B-cell lymphoma — for which ...

#95. Worldwide Car T Cell Therapy Industry to 2028 - Yahoo Finance

Many types of cancer such as diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, mantle cell lymphoma, multiple myeloma, and B-cell ...